Methanol → (R)-Methyl 2-(3-chlorophenyl)-2-hydroxyacetate

HRID 547099노트

반응식

HRID 547099 반응식
C[Si](C=[N+]=[N-])(C)C.[CH3:8]CCCCC.[Cl:14][C:15]1[CH:16]=[C:17]([C@@H:21]([OH:25])[C:22]([OH:24])=[O:23])[CH:18]=[CH:19][CH:20]=1.CO>C1C=CC=CC=1>[CH3:8][O:23][C:22](=[O:24])[C@@H:21]([C:17]1[CH:18]=[CH:19][CH:20]=[C:15]([Cl:14])[CH:16]=1)[OH:25]

참가 물질

6

반응물 4

HCID 887MethanolHCID 8058HexaneHCID 167693TrimethylsilyldiazomethaneHCID 2733127(R)-2-(3-Chlorophenyl)-2-hydroxyacetic acid

생성물 1

HCID 15606324(R)-Methyl 2-(3-chlorophenyl)-2-hydroxyacetate수율 100%

시약·촉매·용매 1

HCID 241Benzene용매

실험 절차

A solution of trimethylsilyldiazomethane in hexane (2 M, 1.5 mL, 3.0 mmol) was added to a solution of (R)-(3-chloro-phenyl)hydroxy-acetic acid (497 mg, 2.66 mmol) in benzene (2.6 mL)-methanol (1.3 mL) under cooling with ice. Then, the ice bath was removed and the mixture was stirred at room temperature for five minutes. The reaction mixture was concentrated under reduced pressure. The residue was purified by silica gel chromatography (hexane/ethyl acetate=3/1) to give the title compound (533 mg, 100%).

후처리

  1. temperatureunder cooling with ice
  2. customThen, the ice bath was removed
  3. concentrationThe reaction mixture was concentrated under reduced pressure
  4. customThe residue was purified by silica gel chromatography (hexane/ethyl acetate=3/1)

출처 및 근거

ORD 기록
ord-acb4e590f4b54af78e766fdbdfa59cb8
출처 데이터셋
uspto-grants-2011_05
특허 번호
US07935688B2

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