Acetic Acid → (3-bromo-4-hydroxy-5-methoxy-phenyl)-acetic Acid Methyl Ester

HRID 547139노트

반응식

HRID 547139 반응식
C[Si](C=[N+]=[N-])(C)C.[Br:8][C:9]1[CH:10]=[C:11]([CH2:18][C:19]([OH:21])=[O:20])[CH:12]=[C:13]([O:16][CH3:17])[C:14]=1[OH:15].[C:22](O)(=O)C>CO.C1(C)C=CC=CC=1>[CH3:22][O:20][C:19](=[O:21])[CH2:18][C:11]1[CH:12]=[C:13]([O:16][CH3:17])[C:14]([OH:15])=[C:9]([Br:8])[CH:10]=1

참가 물질

6

반응물 3

HCID 176Acetic AcidHCID 167693TrimethylsilyldiazomethaneHCID 5198053-Bromo-4-hydroxy-5-methoxyphenylacetic acid

생성물 1

HCID 57443577(3-bromo-4-hydroxy-5-methoxy-phenyl)-acetic Acid Methyl Ester수율 99%

시약·촉매·용매 2

HCID 887Methanol용매HCID 1140Toluene용매

실험 절차

Trimethylsilyldiazomethane (2 M solution in diethyl ether, 0.409 mL, 0.818 mmol) was added to a solution of (3-bromo-4-hydroxy-5-methoxy-phenyl)-acetic acid (150 mg, 0.575 mmol) in methanol (1 mL) and toluene (4 mL), and the mixture was stirred at room temperature for 30 minutes. Acetic acid was added to the reaction mixture to terminate the reaction, and then the mixture was concentrated under reduced pressure to give the target compound as a colorless oil (158 mg, 99%).

후처리

  1. customto terminate
  2. customthe reaction
  3. concentrationthe mixture was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-6b9ba776c6794e07a24d95e6769726de
출처 데이터셋
uspto-grants-2011_05
특허 번호
US07935688B2

반응 노트

불러오는 중…