Acetic Acid → Methyl 2-(5-bromo-2-methoxyphenyl)acetate

HRID 547145

반응식

HRID 547145 반응식
C[Si](C=[N+]=[N-])(C)C.[Br:8][C:9]1[CH:10]=[CH:11][C:12]([O:19][CH3:20])=[C:13]([CH2:15][C:16]([OH:18])=[O:17])[CH:14]=1.[C:21](O)(=O)C>CO.C1(C)C=CC=CC=1>[CH3:21][O:17][C:16](=[O:18])[CH2:15][C:13]1[CH:14]=[C:9]([Br:8])[CH:10]=[CH:11][C:12]=1[O:19][CH3:20]

참가 물질

6

반응물 3

HCID 176Acetic AcidHCID 167693TrimethylsilyldiazomethaneHCID 5553065-Bromo-2-methoxyphenylacetic acid

생성물 1

HCID 21999895Methyl 2-(5-bromo-2-methoxyphenyl)acetate수율 98%

시약·촉매·용매 2

HCID 887Methanol용매HCID 1140Toluene용매

실험 절차

Trimethylsilyldiazomethane (2 M solution in diethyl ether, 0.306 mL, 0.612 mmol) was added to a solution of (5-bromo-2-methoxy-phenyl)-acetic acid (100 mg, 0408 mmol) in methanol (1 mL) and toluene (4 mL), and the mixture was stirred at room temperature for 30 minutes. Acetic acid was added to the reaction mixture to terminate the reaction, and then the mixture was concentrated under reduced pressure to give the target compound as a colorless oil (103.7 mg, 98%).

후처리

  1. customto terminate
  2. customthe reaction
  3. concentrationthe mixture was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-da01d3947f874f5b9db67375d3a68dac
출처 데이터셋
uspto-grants-2011_05
특허 번호
US07935688B2

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