Hydrazine → HCID 178525216, 화합물

HRID 547150

반응식

HRID 547150 반응식
[NH2:1][NH2:2].[O:3]=[C:4]1[C:8]([CH2:9][C:10]([OH:12])=[O:11])=[CH:7][C:6](=O)[O:5]1>C(O)(=O)C>[OH:5][C:6]1[CH:7]=[C:8]([CH2:9][C:10]([OH:12])=[O:11])[C:4](=[O:3])[NH:1][N:2]=1

참가 물질

4

반응물 2

HCID 9321HydrazineHCID 65163Aconitic anhydride

생성물 1

HCID 178525216HCID 178525216, 화합물수율 80.1%

시약·촉매·용매 1

HCID 176Acetic Acid용매

반응 조건

온도
80 °C

실험 절차

A solution of hydrazine (103 mg, 3.21 mmol) in acetic acid (16 mL) was added to (2,5-dioxo-2,5-dihydro-furan-3-yl)acetic acid (500 mg, 3.04 mmol) under cooling with ice, and the mixture was heated with stirring at an external temperature of 76 to 84° C. for one hour. The reaction mixture was concentrated under reduced pressure. The resulting solid was sequentially washed with water, ethanol and ether to give the title compound (414 mg, 80%).

후처리

  1. temperatureunder cooling with ice
  2. temperaturethe mixture was heated
  3. concentrationThe reaction mixture was concentrated under reduced pressure
  4. washThe resulting solid was sequentially washed with water, ethanol and ether

출처 및 근거

ORD 기록
ord-cff7547648714211adb0e715f20ea4c8
출처 데이터셋
uspto-grants-2011_05
특허 번호
US07935688B2

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