Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → HCID 22478250, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | 4-Chloro-2-fluoroaniline | HCID 93898 | — |
| 반응물 | 4,7-Dichloro-6-nitroquinazoline | HCID 10490455 | — |
| 용매 | Acetone | HCID 180 | — |
| 용매 | Isopropanol | HCID 3776 | — |
| 생성물 | HCID 22478250 | HCID 22478250 | 90% |
반응 단계
A mixture of 4,7-dichloro-6-nitroquinazoline (24.4 g, 0.1 mol), 4-chloro-2-fluoroaniline and ethereal hydrogen chloride (100 ml of a 1M solution) in 2-propanol (600 ml) was heated at reflux for 1.5 hours. The mixture was allowed to cool and diluted with acetone. The solid product was collected by filtration, washed with acetone and dried to give 7-chloro-4-(4-chloro-2-fluoroanilino)-6nitroquinazoline hydrochloride (35.0 g, 90%) as a yellow powder.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | USRE042353E1 |
| 출처 데이터셋 | uspto-grants-2011_05 |
| ORD ID | ord-9b64e283a6044048b2a081954f550360 |
| 출처 메모 | uspto-grants-2011_05 |