Benzyl Alcohol → 3,4,4-Trifluoro-3-butenoic acid, phenylmethyl ester

HRID 54732

반응식

HRID 54732 반응식
[F:1][C:2](=[C:7]([F:9])[F:8])[CH2:3][C:4](Cl)=[O:5].[CH2:10]([OH:17])[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>ClCCl>[F:1][C:2](=[C:7]([F:9])[F:8])[CH2:3][C:4]([O:17][CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)=[O:5]

참가 물질

4

반응물 2

HCID 244Benzyl AlcoholHCID 109207893,4,4-Trifluoro-3-butenoyl chloride

생성물 1

HCID 152391893,4,4-Trifluoro-3-butenoic acid, phenylmethyl ester수율 92%

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

A solution of 3,4,4-trifluoro-3-butenoyl chloride (2.8 g, 0.0176 mole) and benzyl alcohol (0.9 g, 0.0083 mole) in 20 mL dichloromethane is heated at reflux for 40 h. The solution is cooled to room temperature, diluted with dichloromethane (15 mL), washed successively with 5% sodium bicarbonate, water and brine, and dried. Evaporation of the solvent gave 1.75 g of analytically pure product as a pale yellow oil, a 92% yield.

후처리

  1. temperatureat reflux for 40 h
  2. washwashed successively with 5% sodium bicarbonate, water and brine
  3. customdried
  4. customEvaporation of the solvent
  5. customgave 1.75 g of analytically pure product as a pale yellow oil

출처 및 근거

ORD 기록
ord-33802d7b13274c35bbbf39266a33b36e
출처 데이터셋
uspto-grants-1997_04
특허 번호
US05623084

연결된 노트

불러오는 중…