1-Octanethiol → 3,4,4-trifluoro-3-butenethioic acid, S-octyl ester

반응식

[F:1][C:2](=[C:7]([F:9])[F:8])[CH2:3][C:4](Cl)=[O:5].[CH2:10]([SH:18])[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17]>>[F:1][C:2](=[C:7]([F:9])[F:8])[CH2:3][C:4](=[O:5])[S:18][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17]

참가 물질

반응물 2

HCID 81441-Octanethiol

HCID 109207893,4,4-Trifluoro-3-butenoyl chloride

생성물 1

HCID 152391923,4,4-trifluoro-3-butenethioic acid, S-octyl ester수율 91.3%

반응 조건

온도: 70 °C

실험 절차

A mixture of 3,4,4-trifluoro-3-butenoyl chloride (1.7 g, 0.0107 mole) and 1-octanethiol (0.72 g, 0.0049 mole) is heated at 70° C. for 12 h. The crude product is purified by passing through a short column of silica gel to give 1.2 g of the desired product as a pale yellow oil, a 91% yield.

후처리

customThe crude product is purified

출처 및 근거

ORD 기록: ord-eb0dbc9d20ca481b847892b364cfb881
출처 데이터셋: uspto-grants-1997_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05623084

반응 노트

불러오는 중…