Oxalyl chloride → 3-(3,4-Difluorophenyl)propanoyl chloride

HRID 547657노트

반응식

HRID 547657 반응식
[F:1][C:2]1[CH:3]=[C:4]([CH:9]([CH3:13])C(O)=O)[CH:5]=[CH:6][C:7]=1[F:8].C(Cl)(=O)[C:15]([Cl:17])=[O:16]>CN(C)C=O.ClCCl>[F:1][C:2]1[CH:3]=[C:4]([CH2:9][CH2:13][C:15]([Cl:17])=[O:16])[CH:5]=[CH:6][C:7]=1[F:8]

참가 물질

5

반응물 2

HCID 65578Oxalyl chlorideHCID 20668528444170-17-6

생성물 1

HCID 575859753-(3,4-Difluorophenyl)propanoyl chloride수율 99.8%

시약·촉매·용매 2

HCID 6228Dimethylformamide촉매HCID 6344Dichloromethane용매

실험 절차

To a dichloromethane solution (200 mL) containing 3,4-difluorophenyl propionic acid (30.45 g, 163.6 mmol) and 2 drops of dimethylformamide was added oxalyl chloride (41.4 g, 327.1 mmol) over 20 min. The resulting solution was stirred for 24 hours at which time the solvent was removed in vacuo. The residual oil was then evaporated with toluene (˜100 mL) yielding 33.4 g of 3-(3,4-difluorophenyl)propanoyl chloride as a yellow liquid, which was taken directly into the next step.

후처리

  1. customwas removed in vacuo
  2. customThe residual oil was then evaporated with toluene (˜100 mL)

출처 및 근거

ORD 기록
ord-4b9e394351084ce69d52571f6696f391
출처 데이터셋
uspto-grants-2011_05
특허 번호
US07939528B2

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