Water → 2-(3,5-Dichlorophenyl)-2-methylpropanoic acid

HRID 547751노트

반응식

HRID 547751 반응식
C[O:2][C:3](=[O:15])[C:4]([C:7]1[CH:12]=[C:11]([Cl:13])[CH:10]=[C:9]([Cl:14])[CH:8]=1)([CH3:6])[CH3:5].O>C(O)C>[Cl:13][C:11]1[CH:12]=[C:7]([C:4]([CH3:6])([CH3:5])[C:3]([OH:15])=[O:2])[CH:8]=[C:9]([Cl:14])[CH:10]=1

참가 물질

4

반응물 2

HCID 962WaterHCID 671939532-(3,5-Dichloro-phenyl)-2-methyl-propionic acid methyl ester

생성물 1

HCID 589907192-(3,5-Dichlorophenyl)-2-methylpropanoic acid수율 98.9%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a solution of 9.0 g (36 mmol) 2-(3,5-dichloro-phenyl)-2-methyl-propionic acid methyl ester in 40 ml ethanol 40 ml 2 N sodium hydroxide solution was added. After stirring for 4 hrs at RT 150 ml water was added and the solution washed twice with 200 ml Et2O. The aqueous phase was acidified with 25% hydrochloric acid solution and three times extracted with 150 ml CH2Cl2. The combined organic layers were dried (Na2SO4), filtered and evaporated to yield 8.3 g (97%) 2-(3,5-dichloro-phenyl)-2-methyl-propionic acid as a off-white solid.

후처리

  1. additionwas added
  2. washthe solution washed twice with 200 ml Et2O
  3. extractionextracted with 150 ml CH2Cl2
  4. dry with materialThe combined organic layers were dried (Na2SO4)
  5. filtrationfiltered
  6. customevaporated

출처 및 근거

ORD 기록
ord-ae7cf2c6725c40ed91ec22883b398bcc
출처 데이터셋
uspto-grants-2011_05
특허 번호
US07939533B2

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