참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Calcium Bromide | HCID 5360316 | — |
| 반응물 | Calcium Hydroxide | HCID 6093208 | — |
| 반응물 | alpha-(2,3-Dibromopropyl)-2,4-difluorobenzenemethanol | HCID 18923963 | — |
| 용매 | Methanol | HCID 887 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | (+/-)-4-Bromo-2-(2,4-difluorophenyl)tetrahydrofuran | HCID 85719042 | 57% |
반응 단계
A mixture of 4.5 g of product from Example 164, 1.67 g of calcium hydroxide, 7.5 g of calcium bromide, 25 ml of water and 12 ml of methyl alcohol is stirred and heated at 85° C. overnight. The reaction mixture is cooled, diluted with ethyl acetate and filtered through diatomaceous earth. The layers are separated and the organic layer is washed with saturated sodium chloride, dried, filtered and concentrated in vacuo. The residue is purified by chromatography (silica gel: 3-5% ethyl acetate/hexane) to give 1.96 g of the desired product as a mixture of isomers.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05623081 |
|---|
| 출처 데이터셋 | uspto-grants-1997_04 |
|---|
| ORD ID | ord-346c59c7b65f4ddba6f8c0daab77efe2 |
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| 출처 메모 | uspto-grants-1997_04 |
|---|
