1-(Bromomethyl)-2-methoxybenzene → 4-(N-(furan-2-ylmethyl)-N-(2-methoxybenzyl)sulfamoyl)benzoic acid

반응식

Br[CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[O:9][CH3:10].[O:11]1[CH:15]=[CH:14][CH:13]=[C:12]1[CH2:16][NH:17][S:18]([C:21]1[CH:29]=[CH:28][C:24]([C:25]([OH:27])=[O:26])=[CH:23][CH:22]=1)(=[O:20])=[O:19]>>[O:11]1[CH:15]=[CH:14][CH:13]=[C:12]1[CH2:16][N:17]([CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[O:9][CH3:10])[S:18]([C:21]1[CH:29]=[CH:28][C:24]([C:25]([OH:27])=[O:26])=[CH:23][CH:22]=1)(=[O:20])=[O:19]

참가 물질

반응물 2

HCID 403081-(Bromomethyl)-2-methoxybenzene

HCID 6815254-[(Furan-2-ylmethyl)sulfamoyl]benzoic acid

생성물 1

HCID 579449274-(N-(furan-2-ylmethyl)-N-(2-methoxybenzyl)sulfamoyl)benzoic acid수율 35%

실험 절차

Prepared as in Example 5-5 from 1-(bromomethyl)-2-methoxybenzene and 4-(N-(furan-2-ylmethyl)sulfamoyl)benzoic acid (Example 5-2b). Yield 35%. MS M+H calculated 402.3, found 402.0.

출처 및 근거

ORD 기록: ord-3a26a968fe3341cebf084e064b6e59ee
출처 데이터셋: uspto-grants-2011_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07939671B2

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