Triethylamine → (S)-2-[[[(4-Nitrophenyl)methoxy]carbonyl]amino]butanoic Acid

HRID 54818노트

반응식

HRID 54818 반응식
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([CH2:10][O:11][C:12](=[O:23])OC2C=CC([N+]([O-])=O)=CC=2)=[CH:6][CH:5]=1)([O-:3])=[O:2].[CH3:24][CH2:25][C@H:26]([NH2:30])[C:27]([OH:29])=[O:28].C(N(CC)CC)C>C(O)C.O>[N+:1]([C:4]1[CH:5]=[CH:6][C:7]([CH2:10][O:11][C:12]([NH:30][C@@H:26]([CH2:25][CH3:24])[C:27]([OH:29])=[O:28])=[O:23])=[CH:8][CH:9]=1)([O-:3])=[O:2]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 80283(-)-2-Aminobutyric acidHCID 21829967Carbonic acid 4-Nitrophenyl (4-Nitrophenyl)methyl Ester

생성물 1

HCID 53667938(S)-2-[[[(4-Nitrophenyl)methoxy]carbonyl]amino]butanoic Acid수율 81.5%

시약·촉매·용매 1

HCID 19096565Water ethanol용매

실험 절차

The title compound is prepared by the procedure of Example 255 using 29.46 g of product from Example 254, 9.5 g of L-2-aminobutyric acid, 25.5 ml of triethylamine and 1112 ml of 4:1 ethyl alcohol/water to give 21.2 g of the desired product after chromatography.

출처 및 근거

ORD 기록
ord-e13a0f63c68d4cbe8884355f7025e3b4
출처 데이터셋
uspto-grants-1997_04
특허 번호
US05623081

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