Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Methylbenzenesulfonic acid → HCID 178477164, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Methylbenzenesulfonic acid | HCID 6925 | — |
| 반응물 | 5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-4-thioribofuranose | HCID 54268469 | — |
| 반응물 | HCID 178418634 | HCID 178418634 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | HCID 178477164 | HCID 178477164 | 67.1% |
반응 단계
Two grams of 5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-4-thioribofuranose (prepared according to J. A. Secrist et al., J. Med. Chem., 1992,35,533) is stirred with 0.456 g of thioacetic acid in 25 ml of methylene chloride and 0.0.025 g of toluenesulfonic acid for 68 hours. On workup the reactiion is adsorbed onto magnesium silicate and then flash chromatographed on silica gel to give 1.5 g of the desired product.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05623081 |
| 출처 데이터셋 | uspto-grants-1997_04 |
| ORD ID | ord-4157e3b36b154ed298b12651e76816a0 |
| 출처 메모 | uspto-grants-1997_04 |