3,6-Dichloro-4-methylpyridazine → 3-Chloro-4-methyl-6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-pyridazine

반응식

[CH3:1][C:2]1[O:6][N:5]=[C:4]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[C:3]=1[CH2:13][OH:14].[Cl:15][C:16]1[N:17]=[N:18][C:19](Cl)=[CH:20][C:21]=1[CH3:22]>>[Cl:15][C:16]1[N:17]=[N:18][C:19]([O:14][CH2:13][C:3]2[C:4]([C:7]3[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=3)=[N:5][O:6][C:2]=2[CH3:1])=[CH:20][C:21]=1[CH3:22]

참가 물질

반응물 2

HCID 879233,6-Dichloro-4-methylpyridazine

HCID 2776149(5-Methyl-3-phenyl-1,2-oxazol-4-yl)methanol

생성물 1

HCID 426296503-Chloro-4-methyl-6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-pyridazine수율 55%

실험 절차

As described for example 4, (5-methyl-3-phenyl-4-isoxazolyl)methanol (5.00 g, 26.4 mmol) was converted using 3,6-dichloro-4-methylpyridazine instead of 3-chloro-6-methylpyridazine to the title compound (4.59 g, 55%) which was obtained as a yellow oil. MS: m/e=316.1 [M]+.

출처 및 근거

ORD 기록: ord-7f03b5419ba54c528c4a4d3b922c9004
출처 데이터셋: uspto-grants-2011_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07943619B2

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