Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetonitrile → (Rs)-s-(3-{[5-bromo-4-(isopropylamino)pyrimidin-2-yl]amino}phenyl)-s-methyl-n-(tolylsulphonyl)sulphimide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetonitrile | HCID 6342 | — |
| 반응물 | chloramine-T trihydrate | HCID 517414 | — |
| 반응물 | 5-Bromo-n4-isopropyl-n2-(3-methylsulphanylphenyl)pyrimidine-2,4-diamine | HCID 59683164 | — |
| 생성물 | (Rs)-s-(3-{[5-bromo-4-(isopropylamino)pyrimidin-2-yl]amino}phenyl)-s-methyl-n-(tolylsulphonyl)sulphimide | HCID 131728843 | — |
반응 단계
In analogy to Example 1, 0.15 g (0.42 mmol) of 5-bromo-N4-isopropyl-N2-(3-methylsulphanylphenyl)pyrimidine-2,4-diamine is reacted with 0.132 g (0.47 mmol) of chloramine-T trihydrate in 3.0 ml of acetonitrile (24 hours). Purification by chromatography (silica gel, ethyl acetate/hexane with ethyl acetate 0-100%, then ethyl acetate/methanol with methanol 5-10% results in 0.14 g (63% of theory) of the product.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07943629B2 |
| 출처 데이터셋 | uspto-grants-2011_05 |
| ORD ID | ord-5f8d6b45db184f5ca026f8130a4e25a7 |
| 출처 메모 | uspto-grants-2011_05 |