Isopropylamine → 2-Chloro-N-isopropyl-4-pyrimidinamine

HRID 548953노트

반응식

HRID 548953 반응식
[Cl:1][C:2]1[N:7]=[C:6](Cl)[CH:5]=[CH:4][N:3]=1.[CH:9]([NH2:12])([CH3:11])[CH3:10].C(N(CC)CC)C>C(#N)C>[Cl:1][C:2]1[N:7]=[C:6]([NH:12][CH:9]([CH3:11])[CH3:10])[CH:5]=[CH:4][N:3]=1

참가 물질

5

반응물 3

HCID 6363IsopropylamineHCID 8471TriethylamineHCID 775312,4-Dichloropyrimidine

생성물 1

HCID 202849702-Chloro-N-isopropyl-4-pyrimidinamine

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

In analogy to compound 1.1, a solution of 0.347 g (2.33 mmol) of 2,4-dichloro-pyrimidine in 15 ml of acetonitrile is reacted with 0.22 ml (2.52 mmol) of isopropylamine in the presence of 0.39 ml (2.83 mmol) of triethylamine. Purification by chromatography (silica gel, ethyl acetate/hexane with ethyl acetate 0-100%) results in 0.26 g (65% of theory) of the product.

후처리

  1. customPurification by chromatography (silica gel, ethyl acetate/hexane with ethyl acetate 0-100%)
  2. customresults in 0.26 g (65% of theory) of the product

출처 및 근거

ORD 기록
ord-195e515122f344739517d1768bca294f
출처 데이터셋
uspto-grants-2011_05
특허 번호
US07943629B2

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