Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dichloromethane → (RS)-S-Methyl-S-(4-nitrophenyl)-N-[(4-chloro-3-pyridyl)sulphonyl]sulphimide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dichloromethane | HCID 6344 | — |
| 반응물 | 4-Nitrophenyl methyl sulfide | HCID 96109 | — |
| 반응물 | Magnesium monoxide | HCID 6850729 | — |
| 반응물 | 5-Chloropyridine-3-sulfonamide | HCID 54594706 | — |
| 반응물 | Acetic acid;iodosylbenzene | HCID 73357407 | — |
| 촉매 | Dirhodium tetraacetate | HCID 152122 | — |
| 생성물 | (RS)-S-Methyl-S-(4-nitrophenyl)-N-[(4-chloro-3-pyridyl)sulphonyl]sulphimide | HCID 59683173 | 46% |
반응 단계
879 mg (2.73 mmol) of iodosobenzene diacetate are added to a suspension of 300 mg (1.77 mmol) of 1-methylsulphanyl-4-nitrobenzene, 683 mg (3.55 mmol) of 5-chloro-3-pyridinesulphonamide, 285 mg (7.10 mmol) of magnesium oxide and 78 mg (0.18 mmol) of rhodium(II) acetate dimer in 12 ml of dichloromethane at room temperature. The mixture is stirred for 24 h and then concentrated. The resulting residue is purified by chromatography (dichloromethane/ethanol 95:5). 294 mg (0.82 mmol; yield: 46%) of the product are obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07943629B2 |
| 출처 데이터셋 | uspto-grants-2011_05 |
| ORD ID | ord-5c9938856bf541adb341dac74ee22871 |
| 출처 메모 | uspto-grants-2011_05 |