Dimethylamine → N,N-Dimethyl-3-nitro-1H-pyrrol-2-amine

HRID 549228노트

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HRID 549228 반응식
Cl[C:2]1[NH:3][CH:4]=[CH:5][C:6]=1[N+:7]([O-:9])=[O:8].[CH3:10][NH:11][CH3:12]>>[CH3:10][N:11]([CH3:12])[C:2]1[NH:3][CH:4]=[CH:5][C:6]=1[N+:7]([O-:9])=[O:8]

참가 물질

3

반응물 2

HCID 674DimethylamineHCID 553005692-chloro-3-nitro-1H-pyrrole

생성물 1

HCID 45121913N,N-Dimethyl-3-nitro-1H-pyrrol-2-amine

반응 조건

온도
100 °C

실험 절차

This compound was prepared in a manner analogous to that set forth in Step C of Example 2, using 0.65 gram (0.0045 mole) of 2-chloro-3-nitropyrrole (prepared in Steps D-F of Example 1) and 5.0 mL (excess) of dimethylamine. The microwave chemical reactor was maintained at 100° C. during a 45-minute period, after which time the reaction was considered to be complete. The crude product was purified with column chromatography on silica gel. Elution was accomplished using 25% hexane in diethyl ether, then 100% diethyl ether as eluants. The appropriate fractions were combined and concentrated under reduced pressure, yielding 0.2 gram of the subject compound. The NMR spectrum was consistent with the proposed structure.

후처리

  1. customThis compound was prepared in a manner analogous to that set forth in Step C of Example 2
  2. customThe crude product was purified with column chromatography on silica gel
  3. washElution
  4. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-a8e431aa4fb14b27bcb644c66a0a0bbe
출처 데이터셋
uspto-grants-2011_05
특허 번호
US07943642B2

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