Potassium Carbonate → {2-[2-(Dimethylamino)-3-nitropyrrolyl]ethyl}[(6-chloro(3-pyridyl))methyl][(4-chlorophenyl)methyl]amine

HRID 549229노트

반응식

HRID 549229 반응식
[Cl:1][C:2]1[N:7]=[CH:6][C:5]([CH2:8][N:9]([CH2:18][CH2:19]Cl)[CH2:10][C:11]2[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][CH:12]=2)=[CH:4][CH:3]=1.[CH3:21][N:22]([CH3:31])[C:23]1[NH:24][CH:25]=[CH:26][C:27]=1[N+:28]([O-:30])=[O:29].C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[CH3:21][N:22]([CH3:31])[C:23]1[NH:24][CH:25]=[C:26]([CH2:19][CH2:18][N:9]([CH2:8][C:5]2[CH:6]=[N:7][C:2]([Cl:1])=[CH:3][CH:4]=2)[CH2:10][C:11]2[CH:12]=[CH:13][C:14]([Cl:17])=[CH:15][CH:16]=2)[C:27]=1[N+:28]([O-:30])=[O:29]

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 45121913N,N-Dimethyl-3-nitro-1H-pyrrol-2-amineHCID 86624870(6-Chloro(3-pyridyl)methyl](2-chloroethyl)[(4-chlorophenyl)methyl]amine

생성물 1

HCID 86624871{2-[2-(Dimethylamino)-3-nitropyrrolyl]ethyl}[(6-chloro(3-pyridyl))methyl][(4-chlorophenyl)methyl]amine

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

This compound was prepared in a manner analogous to that set forth in Step G of Example 1, using 0.47 gram (0.0014 mole) of [(6-chloro(3-pyridyl)methyl](2-chloroethyl)[(4-chlorophenyl)methyl]amine (prepared in Steps A and B of the present Example), 0.2 gram (0.0013 mole) of dimethyl(3-nitropyrrol-2-yl)amine and 0.45 gram (0.0032 mole) of potassium carbonate in 20 mL of DMF. The crude product was purified with column chromatography on silica gel. Elution was accomplished using 50% hexane in diethyl as an eluant. The appropriate fractions were combined and concentrated under reduced pressure, yielding 0.05 gram of Compound 214. The NMR spectrum was consistent with the proposed structure.

후처리

  1. customThis compound was prepared in a manner analogous to that set forth in Step G of Example 1
  2. customThe crude product was purified with column chromatography on silica gel
  3. washElution
  4. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-e6894f8dcb064c0eaed8eda8d7f4875a
출처 데이터셋
uspto-grants-2011_05
특허 번호
US07943642B2

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