Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Trifluoroacetic acid → (RS)-2-(5-Phenyl-[1,3,4]oxadiazol-2-ylmethyl)-piperidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Trifluoroacetic acid | HCID 6422 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | (RS)-2-(5-Phenyl-[1,3,4]oxadiazol-2-ylmethyl)-piperidine-1-carboxylic acid tert butyl ester | HCID 86628996 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | (RS)-2-(5-Phenyl-[1,3,4]oxadiazol-2-ylmethyl)-piperidine | HCID 67157689 | 92.8% |
반응 단계
A solution of (RS)-2-(5-phenyl-[1,3,4]oxadiazol-2-ylmethyl)-piperidine-1-carboxylic acid tert butyl ester (0.175 g) in dichloromethane (4 ml) was cooled (ice bath) and treated with trifluoroacetic acid (1 ml). The mixture was stirred for 1 h, added to saturated potassium carbonate and the product extracted into dichloromethane. The organic phase was dried (MgSO4) and solvent removed at reduced pressure to give the title compound (0.115 g)
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07943645B2 |
| 출처 데이터셋 | uspto-grants-2011_05 |
| ORD ID | ord-87e2773e6e7042bfb799c4cc0a702471 |
| 출처 메모 | uspto-grants-2011_05 |