Potassium Iodide → HCID 28881253, 화합물

HRID 549379

반응식

HRID 549379 반응식
[CH3:1][C:2]1[NH:3][C:4]2[C:9]([CH:10]=1)=[CH:8][CH:7]=[CH:6][CH:5]=2.Br[CH2:12][C:13]([O-:15])=[O:14].C(=O)([O-])[O-].[Cs+].[Cs+].[I-].[K+].[C:24](#N)[CH3:25]>C(OCC)(=O)C>[CH2:24]([O:15][C:13](=[O:14])[CH2:12][N:3]1[C:4]2[C:9](=[CH:8][CH:7]=[CH:6][CH:5]=2)[CH:10]=[C:2]1[CH3:1])[CH3:25]

참가 물질

7

반응물 5

HCID 4875Potassium IodideHCID 6226BromoacetateHCID 6342AcetonitrileHCID 72242-MethylindoleHCID 10796Cesium carbonate

생성물 1

HCID 28881253HCID 28881253, 화합물수율 82%

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

A solution of 2-methyl-1H-indole (1.0 g, 7.6 mmol) in acetonitrile (25 mL) was treated with 2-bromoacetate (2.54 mL, 22.9 mmol), cesium carbonate (2.10 g, 11.4 mmol) and potassium iodide (253 mg, 1.52 mmol) and the resulting mixture was stirred at room temperature for 16 h. The mixture was diluted with ethyl acetate, washed with water and brine, dried over sodium sulfate, filtered, and concentrated, and the residue was purified to give (2-methyl-indol-1-yl)-acetic acid ethyl ester (1.36 g, 82% yield). LCMS (m/z): 218.1 (M+1).

후처리

  1. washwashed with water and brine
  2. dry with materialdried over sodium sulfate
  3. filtrationfiltered
  4. concentrationconcentrated
  5. customthe residue was purified

출처 및 근거

ORD 기록
ord-4a055437874c42678fffdf958803417e
출처 데이터셋
uspto-grants-2011_05
특허 번호
US07943652B2

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