참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Sulfur | HCID 5362487 | — |
| 반응물 | 3-(1-Acetyl-l,2-dihydro-2-methylpyridin-4-yl)-2-(4-fluorophenyl)pyrazolo[1,5-a]pyrimidine | HCID 19957261 | — |
| 용매 | Decalin | HCID 7044 | — |
| 생성물 | 2-(4-Fluorophenyl)-3-(2-methylpyridin-4-yl)pyrazolo[1,5-a]pyrimidine | HCID 19957277 | 49.1% |
반응 단계
A mixture of 3-(1-acetyl-1,2-dihydro-2-methylpyridin-4-yl)-2-(4-fluorophenyl)pyrazolo[1,5-a]pyrimidine (315 mg) and sulfur (146 mg) in decaline (3 ml) was stirred at 190° C. for 2 hours. The reaction mixture was cooled and purified by column chromatography on silica gel to give 2-(4-fluorophenyl)-3-(2-methylpyridin-4-yl)pyrazolo[1,5-a]pyrimidine (135 mg) as crystals.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05624931 |
|---|
| 출처 데이터셋 | uspto-grants-1997_04 |
|---|
| ORD ID | ord-3ed64ac8d49e4086a99c392c103b6c7c |
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| 출처 메모 | uspto-grants-1997_04 |
|---|
