Imidazole → HCID 11437113, 화합물

HRID 549511

반응식

HRID 549511 반응식
N1C=CN=C1.[CH2:6]=[CH:7][CH2:8][CH:9]([OH:13])[CH2:10][CH:11]=[CH2:12].[CH:14]([Si:17](Cl)([CH:21]([CH3:23])[CH3:22])[CH:18]([CH3:20])[CH3:19])([CH3:16])[CH3:15]>O>[CH:14]([Si:17]([CH:21]([CH3:23])[CH3:22])([CH:18]([CH3:20])[CH3:19])[O:13][CH:9]([CH2:10][CH:11]=[CH2:12])[CH2:8][CH:7]=[CH2:6])([CH3:16])[CH3:15]

참가 물질

5

반응물 3

HCID 795ImidazoleHCID 17902Hepta-1,6-dien-4-olHCID 139400Triisopropylsilyl chloride

생성물 1

HCID 11437113HCID 11437113, 화합물수율 46%

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
0 °C

실험 절차

There was supplied 1.35 g of imidazole manufactured by Wako Pure Chemical Industries, Ltd. to a 50 mL-Schlenk tube, and thereto, 10 mL of anhydrous N,N-dimethylformaide manufactured by Wako Pure Chemical Industries, Ltd., and 1.2 mL of 1,6-heptadien-4-ol manufactured by Aldrich Chemical Company were added. The obtained mixture was cooled down to 0° C. To the mixture, 1.93 mL of triisopropylsilyl chloride manufactured by Tokyo Chemical Industry Co., Ltd. was added, and the resultant mixture was stirred for 85 hours at a room temperature. Then, an excess amount of water was added thereto, thereby terminating the reaction. A product contained in the reaction mixture was extracted with hexane, and the obtained organic extract was dried over anhydrous sodium sulfate manufactured by Nacalai Tesque, Inc. The dried hexane solution was distilled in vacuo, thereby obtaining 1.1 g (yield: 46%) of 4-(triisopropylsiloxy)-1,6-heptadiene at 93° C. under 21 mmHg as clear colorless oil.

후처리

  1. additionwere added
  2. additionwas added
  3. customterminating
  4. customthe reaction
  5. extractionwas extracted with hexane
  6. extractionthe obtained organic extract
  7. dry with materialwas dried over anhydrous sodium sulfate
  8. distillationThe dried hexane solution was distilled in vacuo

출처 및 근거

ORD 기록
ord-858f803cdc954b77844d9d005ce30940
출처 데이터셋
uspto-grants-2011_05
특허 번호
US07943715B2

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