2,6-Diacetylpyridine → HCID 17799625, 화합물

HRID 549512

반응식

HRID 549512 반응식
[C:1]([C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([C:10](=O)[CH3:11])[N:5]=1)(=O)[CH3:2].[CH3:13][C:14]1[CH:20]=[CH:19][CH:18]=[C:17]([CH:21]([CH3:23])[CH3:22])[C:15]=1[NH2:16]>C(O)(=O)C.C(O)C>[CH3:13][C:14]1[CH:20]=[CH:19][CH:18]=[C:17]([CH:21]([CH3:23])[CH3:22])[C:15]=1[N:16]=[C:1]([C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([C:10](=[N:16][C:15]2[C:17]([CH:21]([CH3:22])[CH3:23])=[CH:18][CH:19]=[CH:20][C:14]=2[CH3:13])[CH3:11])[N:5]=1)[CH3:2]

참가 물질

5

반응물 2

HCID 707902,6-DiacetylpyridineHCID 789206-Isopropyl-o-toluidine

생성물 1

HCID 17799625HCID 17799625, 화합물수율 35%

시약·촉매·용매 2

HCID 176Acetic Acid촉매HCID 702Ethanol용매

실험 절차

There were supplied 325 mg of 2,6-diacetylpyridine manufactured by Aldrich Chemical Company to a 25 mL-Schlenk tube. Thereto, 5 mL of anhydrous ethanol manufactured by Kanto Chemical Co., Inc., 0.62 mL of 2-methyl-6-isopropylaniline manufactured by Tokyo Chemical Industry Co., Ltd., and a few drops of acetic acid manufactured by Kanto Chemical Co., Inc. were added. The obtained mixture was refluxed for 24 hours. Then, the solvent contained in the mixture was distilled off, and the resultant mixture was subjected to recrystallization with methanol, thereby obtaining 298 mg (yield: 35%) of 2,6-bis[1-(2-methyl-6-isopropylphenylimino)ethyl]pyridine as a yellow powder.

후처리

  1. additionwere added
  2. temperatureThe obtained mixture was refluxed for 24 hours
  3. distillationwas distilled off
  4. customthe resultant mixture was subjected to recrystallization with methanol

출처 및 근거

ORD 기록
ord-79a02e5243044b51af20c6dbb71ad00f
출처 데이터셋
uspto-grants-2011_05
특허 번호
US07943715B2

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