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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 549953생성일: 2026년 10월 26일

2-(5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetic acid → 1-{4-[5-Bromo-4-(2-phenylethyl)-1,3-thiazol-2-yl]piperidin-1-yl}-2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]ethanone

https://huagongshe.com/reaction/549953

반응식

참여 물질

역할이름HCID투입량
반응물2-(5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetic acidHCID 596118—
반응물4-[5-Bromo-4-(2-phenylethyl)-1,3-thiazol-2-yl]piperidineHCID 67156856—
생성물1-{4-[5-Bromo-4-(2-phenylethyl)-1,3-thiazol-2-yl]piperidin-1-yl}-2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]ethanoneHCID 67156400—

반응 단계

4-[5-Bromo-4-(2-phenylethyl)-1,3-thiazol-2-yl]piperidine (II-3, 127 mg) is reacted analogously to Example I-81 with [5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetic acid (118 mg). After chromatographic purification, this gives 1-{4-[5-bromo-4-(2-phenylethyl)-1,3-thiazol-2-yl]piperidin-1-yl}-2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]ethanone (52 mg).

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US07943774B2
출처 데이터셋uspto-grants-2011_05
ORD IDord-d75b1d47eb9449578b9109e441a24501
출처 메모uspto-grants-2011_05