5-Bromo-2-methylbenzoic acid → 5-Bromo-1-(5-(3-chlorophenyl)-2-thienylmethyl)-2-methylbenzene

반응식

[Cl:1][C:2]1[CH:3]=[C:4]([C:8]2[S:9][CH:10]=[CH:11][CH:12]=2)[CH:5]=[CH:6][CH:7]=1.[Br:13][C:14]1[CH:15]=[CH:16][C:17]([CH3:23])=[C:18]([CH:22]=1)[C:19](O)=O>>[Br:13][C:14]1[CH:15]=[CH:16][C:17]([CH3:23])=[C:18]([CH2:19][C:10]2[S:9][C:8]([C:4]3[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[CH:3]=3)=[CH:12][CH:11]=2)[CH:22]=1

참가 물질

반응물 2

HCID 3460045-Bromo-2-methylbenzoic acid

HCID 123624442-(3-Chlorophenyl)thiophene

생성물 1

HCID 666084005-Bromo-1-(5-(3-chlorophenyl)-2-thienylmethyl)-2-methylbenzene

실험 절차

2-(3-Chlorophenyl)thiophene obtained in Reference Example 85-(1) and 5-bromo-2-methylbenzoic acid obtained in Reference Example 4-(1) were treated in a manner similar to Reference Example 5 to give the target compound as colorless oil.

후처리

addition4-(1) were treated in a manner similar to Reference Example 5

출처 및 근거

ORD 기록: ord-598b3dcc8ffa4abdad26d6bd2ae5d467
출처 데이터셋: uspto-grants-2011_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07943788B2

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