2-Thiophenecarboxaldehyde, 5-chloro- → 4-Bromo-2-(5-chloro-2-thienylmethyl)-1-methoxynaphthalene

반응식

Br[C:2]1[CH:11]=[C:10]([Br:12])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]=1[O:13][CH3:14].[Cl:15][C:16]1[S:20][C:19]([CH:21]=O)=[CH:18][CH:17]=1>>[Br:12][C:10]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([O:13][CH3:14])=[C:2]([CH2:21][C:19]2[S:20][C:16]([Cl:15])=[CH:17][CH:18]=2)[CH:11]=1

참가 물질

반응물 2

HCID 817002-Thiophenecarboxaldehyde, 5-chloro-

HCID 35720592,4-Dibromo-1-methoxynaphthalene

생성물 1

HCID 666078244-Bromo-2-(5-chloro-2-thienylmethyl)-1-methoxynaphthalene

실험 절차

2,4-Dibromo-1-methoxynaphthalene (see Org. Lett. (2003) 5, 831) and 5-chloro-2-thiophenecarboxaldehyde were treated in a manner similar to Reference Example 1 to give 4-Bromo-2-(5-chloro-2-thienylmethyl)-1-methoxynaphthalene.

출처 및 근거

ORD 기록: ord-2708f7893b0749749ce022132bec25b2
출처 데이터셋: uspto-grants-2011_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07943788B2

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