Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-Bromomethyl-2,6-dichlorobenzene → 1-(2,6-Dichlorobenzyl)-3-[1-(6,7-dimethoxy-4-quinazolinyl)-4-piperidinyl]-1,2,3,4-tetrahydro-6-nitro-2,4-dioxoquinazoline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-Bromomethyl-2,6-dichlorobenzene | HCID 30159 | — |
| 반응물 | 3-[1-(6,7-Dimethoxy-4-quinazolinyl)-4-piperidinyl]-1,2,3,4-tetrahydro-6-nitro-2,4-dioxoquinazoline | HCID 22923399 | — |
| 생성물 | 1-(2,6-Dichlorobenzyl)-3-[1-(6,7-dimethoxy-4-quinazolinyl)-4-piperidinyl]-1,2,3,4-tetrahydro-6-nitro-2,4-dioxoquinazoline | HCID 22923555 | 29% |
반응 단계
The procedure similar to that described in Example 1 was repeated, except that 300 mg (0.63 mmol) of Compound 24 was used and 2,6-dichlorobenzyl bromide was used in place of methyl iodide. As a result, 117.1 mg (yield: 29%) of Compound 10 was obtained as pale yellow crystals.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05624926 |
| 출처 데이터셋 | uspto-grants-1997_04 |
| ORD ID | ord-c9f7607c9cc145cbb5f7356aba12dec0 |
| 출처 메모 | uspto-grants-1997_04 |