Water → 4-(4-methyl-5-phenyl-4H-1,2,4-triazol-3-yl)butanal

HRID 550532노트

반응식

HRID 550532 반응식
[CH3:1][N:2]1[C:6]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)=[N:5][N:4]=[C:3]1[CH2:13][CH2:14][CH2:15][CH:16]=C.[OH2:18]>C1COCC1.O.O=[Os](=O)(=O)=O>[CH3:1][N:2]1[C:6]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)=[N:5][N:4]=[C:3]1[CH2:13][CH2:14][CH2:15][CH:16]=[O:18]

참가 물질

5

반응물 2

HCID 962WaterHCID 576918864-methyl-3-(4-penten-1-yl)-5-phenyl-4H-1,2,4-triazole

생성물 1

HCID 576919404-(4-methyl-5-phenyl-4H-1,2,4-triazol-3-yl)butanal

시약·촉매·용매 2

HCID 30318Osmium Tetroxide촉매HCID 21881883Oxolane--water (1/1)용매

실험 절차

To a solution of 4-methyl-3-(4-penten-1-yl)-5-phenyl-4H-1,2,4-triazole (196 mg, 0.86 mmol) in THF/H2O (7.5/1.5 ml) were added OsO4 (4% solution in water, 0.04 mmol) and NalO4 (2.6 mmol). The solution was stirred o.n. at r.t. Water was added and product was extract with DCM. The organic phase was separated, dried over Na2SO4 and filtered. Volatiles were evaporated in vacuo to give 178 mg of the title compound as an oil, which was used in the subsequent step without further purification.

후처리

  1. customat r.t
  2. extractionproduct was extract with DCM
  3. customThe organic phase was separated
  4. dry with materialdried over Na2SO4
  5. filtrationfiltered
  6. customVolatiles were evaporated in vacuo

출처 및 근거

ORD 기록
ord-c49a722371214ade98e4657b7462a3f9
출처 데이터셋
uspto-grants-2011_05
특허 번호
US07947683B2

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