5-Bromopyrimidine → 6-Methyl-3-(pyrimidin-5-ylamino)-pyrazine-2-carboxylic acid (5-fluoro-pyridin-2-yl)-amide

반응식

C(O[C:4]([C:6]1[C:11]([NH2:12])=[N:10][CH:9]=[C:8]([CH3:13])[N:7]=1)=[O:5])C.Br[C:15]1[CH:16]=[N:17][CH:18]=[N:19][CH:20]=1.[NH2:21][C:22]1[CH:27]=[CH:26][C:25]([F:28])=[CH:24][N:23]=1>>[F:28][C:25]1[CH:26]=[CH:27][C:22]([NH:21][C:4]([C:6]2[C:11]([NH:12][C:15]3[CH:16]=[N:17][CH:18]=[N:19][CH:20]=3)=[N:10][CH:9]=[C:8]([CH3:13])[N:7]=2)=[O:5])=[N:23][CH:24]=1

참가 물질

반응물 3

HCID 783445-Bromopyrimidine

HCID 317738Ethyl 3-amino-6-methylpyrazine-2-carboxylate

HCID 27377012-Amino-5-fluoropyridine

생성물 1

HCID 119964756-Methyl-3-(pyrimidin-5-ylamino)-pyrazine-2-carboxylic acid (5-fluoro-pyridin-2-yl)-amide

실험 절차

The title compound, MS: m/e=326.3 (M+H+), was prepared in accordance with the general method of example 10 from 3-amino-6-methyl-pyrazine-2-carboxylic acid ethyl ester (Example C), 5-bromopyrimidine and 2-amino-5-fluoropyridine.

출처 및 근거

ORD 기록: ord-c847970dd0f14e25bf8fd20b59ca0d5d
출처 데이터셋: uspto-grants-2011_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07947685B2

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