Hydrazine → Methyl 3-amino-2,2-dimethylpropanoate

HRID 550595노트

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HRID 550595 반응식
NN.O=C1C2C(=CC=CC=2)C(=O)[N:5]1[CH2:14][C:15]([CH3:21])([CH3:20])[C:16]([O:18][CH3:19])=[O:17]>CO.C(OCC)C>[NH2:5][CH2:14][C:15]([CH3:21])([CH3:20])[C:16]([O:18][CH3:19])=[O:17]

참가 물질

5

반응물 2

HCID 9321HydrazineHCID 11173032methyl 3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-2,2-dimethylpropanoate

생성물 1

HCID 13285789Methyl 3-amino-2,2-dimethylpropanoate수율 75%

시약·촉매·용매 2

HCID 887Methanol용매HCID 3283Diethyl Ether용매

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온도
65 °C

실험 절차

Hydrazine (1.1 eq., 0.27 mL, 8.42 mmol) was added to the solution of methyl 3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-2,2-dimethylpropanoate (0.2 g, 7.66 mmol) in methanol (60 mL) maintained under magnetic stirring at 65° C. After 5 hours the reaction mixture was allowed to cool to room temperature, diluted with diethyl ether and filtered. The filtrate was washed thoroughly with diethyl ether. The title compound was obtained after evaporation of the solvents and it was used in the next step without any further purification. (0.8 g, 75% yield).

후처리

  1. temperaturemaintained
  2. temperatureto cool to room temperature
  3. filtrationfiltered
  4. washThe filtrate was washed thoroughly with diethyl ether

출처 및 근거

ORD 기록
ord-32d89bb6a91c4421868a5048b955acc7
출처 데이터셋
uspto-grants-2011_05
특허 번호
US07947686B2

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