Ethyl trifluoroacetate → 2,2,2-trifluoro-N-[2-(thiophen-2-yl)ethyl]acetamide

반응식

[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][CH2:7][NH2:8].[F:9][C:10]([F:17])([F:16])[C:11](OCC)=[O:12]>>[F:9][C:10]([F:17])([F:16])[C:11]([NH:8][CH2:7][CH2:6][C:2]1[S:1][CH:5]=[CH:4][CH:3]=1)=[O:12]

참가 물질

반응물 2

HCID 9794Ethyl trifluoroacetate

HCID 116521Thiopheneethanamine

생성물 1

HCID 571304842,2,2-trifluoro-N-[2-(thiophen-2-yl)ethyl]acetamide수율 86%

실험 절차

In close analogy to the procedure described above, 2-Thiophen-2-yl-ethylamine is reacted with ethyl trifluoracetate to provide the. title compound.

후처리

customto provide the

출처 및 근거

ORD 기록: ord-5b0027aece1040d094547082759cd9ac
출처 데이터셋: uspto-grants-2011_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07947689B2

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