6-Bromopyrazolo[1,5-a]pyrimidine-2-carboxylic acid → (6-Bromo-pyrazolo[1,5-a]pyrimidin-2-yl)-(6-methyl-6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)-methanone

반응식

[Br:1][C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([C:11]([OH:13])=O)[CH:10]=2)[CH:7]=1.[CH3:14][CH:15]1[NH:20][CH2:19][C:18]2[CH:21]=[CH:22][S:23][C:17]=2[CH2:16]1>>[Br:1][C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([C:11]([N:20]3[CH:15]([CH3:14])[CH2:16][C:17]4[S:23][CH:22]=[CH:21][C:18]=4[CH2:19]3)=[O:13])[CH:10]=2)[CH:7]=1

참가 물질

반응물 2

HCID 7719386-Bromopyrazolo[1,5-a]pyrimidine-2-carboxylic acid

HCID 203219916-Methyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridine

생성물 1

HCID 24898769(6-Bromo-pyrazolo[1,5-a]pyrimidin-2-yl)-(6-methyl-6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)-methanone수율 62%

실험 절차

In close analogy to the procedure described in Example 1, 6-bromo-pyrazolo[1,5-a]pyrimidine-2-carboxylic acid is reacted with 6-Methyl-4,5,6,7-tetrahydro-thieno[3,2-c]pyridine to provide the title compound.

출처 및 근거

ORD 기록: ord-dc9bae6716a742cd855d7cfff2c3549c
출처 데이터셋: uspto-grants-2011_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07947689B2

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