6-Bromopyrazolo[1,5-a]pyrimidine-2-carboxylic acid → (6-Bromo-pyrazolo[1,5-a]pyrimidin-2-yl)-(2-fluoro-4-methyl-6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)-methanone

반응식

[Br:1][C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([C:11]([OH:13])=O)[CH:10]=2)[CH:7]=1.[F:14][C:15]1[S:23][C:22]2[CH2:21][CH2:20][NH:19][CH:18]([CH3:24])[C:17]=2[CH:16]=1>>[Br:1][C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([C:11]([N:19]3[CH2:20][CH2:21][C:22]4[S:23][C:15]([F:14])=[CH:16][C:17]=4[CH:18]3[CH3:24])=[O:13])[CH:10]=2)[CH:7]=1

참가 물질

반응물 2

HCID 7719386-Bromopyrazolo[1,5-a]pyrimidine-2-carboxylic acid

HCID 671901662-Fluoro-4-methyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridine

생성물 1

HCID 24898993(6-Bromo-pyrazolo[1,5-a]pyrimidin-2-yl)-(2-fluoro-4-methyl-6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)-methanone

실험 절차

In close analogy to the procedure described in Example 1, 6-bromo-pyrazolo[1,5-a]pyrimidine-2-carboxylic acid is reacted with 2-fluoro-4-methyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridine to provide the title compound in moderate yield.

출처 및 근거

ORD 기록: ord-dd1ec27beb73419ab0b9de8e8804add9
출처 데이터셋: uspto-grants-2011_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07947689B2

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