6-Chloropyrazolo[1,5-A]pyrimidine-2-carboxylic acid → 6-Chloro-2-[(4-methyl-6,7-dihydrofuro[3,2-c]pyridin-5(4H)-yl)carbonyl]pyrazolo[1,5-a]pyrimidine

반응식

[Cl:1][C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([C:11]([OH:13])=O)[CH:10]=2)[CH:7]=1.[CH3:14][CH:15]1[C:20]2[CH:21]=[CH:22][O:23][C:19]=2[CH2:18][CH2:17][NH:16]1>>[Cl:1][C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([C:11]([N:16]3[CH2:17][CH2:18][C:19]4[O:23][CH:22]=[CH:21][C:20]=4[CH:15]3[CH3:14])=[O:13])[CH:10]=2)[CH:7]=1

참가 물질

반응물 2

HCID 336956786-Chloropyrazolo[1,5-A]pyrimidine-2-carboxylic acid

HCID 552074534-Methyl-4,5,6,7-tetrahydro-furo[3,2-c]pyridine

생성물 1

HCID 248992376-Chloro-2-[(4-methyl-6,7-dihydrofuro[3,2-c]pyridin-5(4H)-yl)carbonyl]pyrazolo[1,5-a]pyrimidine수율 49%

실험 절차

In close analogy to the procedure described in Example 1, 6-chloro-pyrazolo[1,5-a]pyrimidine-2-carboxylic acid is reacted with 4-Methyl-4,5,6,7-tetrahydro-furo[3,2-c]pyridine to provide the title compound.

출처 및 근거

ORD 기록: ord-7e892cc1fc6c49a9a2accf43e55d3e92
출처 데이터셋: uspto-grants-2011_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07947689B2

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