Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Aminothiophenol → 4-(4-Aminophenylthio)-7-trifluoromethylquinoline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Aminothiophenol | HCID 14510 | — |
| 반응물 | 4-Chloro-7-(trifluoromethyl)quinoline | HCID 67668 | — |
| 촉매 | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 4-(4-Aminophenylthio)-7-trifluoromethylquinoline | HCID 18971671 | 74.1% |
반응 단계
4-Chloro-7-trifluoromethylquinoline (0.043 moles, 10.0 g), 4-aminothiophenol (0.043 moles, 5.3 g) and 4-dimethylaminopyridine (0.04 moles, 4.9 g) were stirred in 250 ml ethanol for 3 days. The reaction mixture was filtered, concentrated, ethyl acetate added, washed with water and dried over sodium sulfate. The solution was concentrated and the product purified by HPLC over silica gel eluted with 25% ethyl acetate/hexane to yield 4-(4-aminophenylthio)-7-trifluoromethylquinoline 10.2 g, 74%. Mass Spec (FD) 320. Calculated for C16H11F3N2S: C, 59.99; H, 3.46; N, 8.74. Found: C, 60.08; H, 3.49; N, 8.77.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05624937 |
| 출처 데이터셋 | uspto-grants-1997_04 |
| ORD ID | ord-3f3c49436bc044d2a8d9d94e039ec63e |
| 출처 메모 | uspto-grants-1997_04 |