Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Toluene → 1-Pyrrolidineacetic acid, ethyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Toluene | HCID 1140 | — |
| 반응물 | Ethyl bromoacetate | HCID 7748 | — |
| 반응물 | Pyrrolidine | HCID 31268 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 1-Pyrrolidineacetic acid, ethyl ester | HCID 210996 | — |
반응 단계
To an ice bath-cooled solution of 213.4 g (3 mol) of pyrrolidine in 450 mL of tetrahydrofuran was added dropwise over about 2 hours 250.5 g (1.5 mol) of ethyl bromoacetate, maintaining the temperature below 30° C. To this solution was added 150 mL of toluene to precipitate pyrrolidinium bromide, which was separated by filtration. The filtrate was evaporated under vacuum to provide a residue of about 241 g of ethyl 1-pyrrolinidineacetate.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05244997 |
| 출처 데이터셋 | uspto-grants-1993_09 |
| ORD ID | ord-e8381d73f4f9423dbff70d4f1bb4f249 |
| 출처 메모 | uspto-grants-1993_09 |