Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Nitrobenzenethiol → 2-[(4-Nitrophenyl)sulfanyl]-1H-benzimidazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Nitrobenzenethiol | HCID 15809 | — |
| 반응물 | 2-Chlorobenzimidazole | HCID 78572 | — |
| 반응물 | 1,8-Diazabicyclo(5.4.0)undec-7-ene | HCID 81184 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 2-[(4-Nitrophenyl)sulfanyl]-1H-benzimidazole | HCID 12617625 | 15.3% |
반응 단계
2-Chlorobenzimidazole (0.033 moles, 5.0 g), 4-nitrothiophenol (0.033 moles, 4.14 g), and DBU (0.033 moles, 5.0 g) in 200 ml ethanol were heated at 55° C. for 3 hr. The reaction was concentrated, ethyl acetate added, washed with water, dried over sodium sulfate and the solvent removed. The solid was slurred in hexane to yield 2-(4-nitrophenylthio)benzimidazole 1.37 g, 15%. Mass Spec (FD) 271. Calculated for C13H8N3O2S: C, 57.55; H, 3.34; N, 15.49. Found: C, 57.50; H, 5.54; N, 15.23.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05624937 |
| 출처 데이터셋 | uspto-grants-1997_04 |
| ORD ID | ord-e19f3c68bd474193823c5cefc616e6b8 |
| 출처 메모 | uspto-grants-1997_04 |