Trifluoroacetic acid → 1-[2-Methoxy-1-(3-trifluoromethyl-phenyl)-ethyl]-piperazine trifluoroacetate

HRID 550844노트

반응식

HRID 550844 반응식
C(OC([N:8]1[CH2:13][CH2:12][N:11]([CH:14]([C:18]2[CH:23]=[CH:22][CH:21]=[C:20]([C:24]([F:27])([F:26])[F:25])[CH:19]=2)[CH2:15][O:16][CH3:17])[CH2:10][CH2:9]1)=O)(C)(C)C.[F:28][C:29]([F:34])([F:33])[C:30]([OH:32])=[O:31]>>[F:28][C:29]([F:34])([F:33])[C:30]([OH:32])=[O:31].[CH3:17][O:16][CH2:15][CH:14]([N:11]1[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1)[C:18]1[CH:23]=[CH:22][CH:21]=[C:20]([C:24]([F:26])([F:27])[F:25])[CH:19]=1

참가 물질

3

반응물 2

HCID 6422Trifluoroacetic acidHCID 590119454-[2-Methoxy-1-(3-trifluoromethyl-phenyl)-ethyl]-piperazine-1-carboxylic acid tert-butyl ester

생성물 1

HCID 866165091-[2-Methoxy-1-(3-trifluoromethyl-phenyl)-ethyl]-piperazine trifluoroacetate

실험 절차

A mixture of 4-[2-Methoxy-1 -(3-trifluoromethyl-phenyl)-ethyl]-piperazine-1-carboxylic acid tert-butyl ester (150 mg, 0.387 mmoles) in neat trifluoroacetic acid (3 mL) was stirred at room temperature for one hour. The mixture was concentrated to dryness and pumped on high vacuum to give 1-[2-Methoxy-1-(3-trifluoromethyl-phenyl)-ethyl]-piperazine trifluoroacetate as an oil. The material was used in the next step without further purification.

후처리

  1. concentrationThe mixture was concentrated to dryness

출처 및 근거

ORD 기록
ord-41fde793a015490e842703454f9fb29b
출처 데이터셋
uspto-grants-2011_05
특허 번호
US07947692B2

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