Potassium Carbonate → 2-(4-Nitrophenylthio)quinoline

HRID 55094

반응식

HRID 55094 반응식
Cl[C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[N+:12]([C:15]1[CH:20]=[CH:19][C:18]([SH:21])=[CH:17][CH:16]=1)([O-:14])=[O:13].C(=O)([O-])[O-].[K+].[K+]>C(O)C>[N+:12]([C:15]1[CH:20]=[CH:19][C:18]([S:21][C:2]2[CH:11]=[CH:10][C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[N:3]=2)=[CH:17][CH:16]=1)([O-:14])=[O:13]

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 119282-ChloroquinolineHCID 158094-Nitrobenzenethiol

생성물 1

HCID 189716432-(4-Nitrophenylthio)quinoline수율 77%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

2-Chloroquinoline (0.12 moles, 20.0 g), 4-nitrothiophenol (0.13 moles, 20.8 g), and potassium carbonate (0.13 moles, 18.5 g) were dissolved in 800 ml ethanol and stirred at room temperature for 1.5 hr. The mixture was filtered and the solid washed with ethanol. The solid was dissolved with ethyl acetate, washed with water, dried over sodium sulfate and concentrated to yield 2-(4-nitrophenylthio)quinoline 26.0 g, 77%. Mass Spec (FD) 282. Calculated for C15H10N2O2S: C, 63.82, H 3.57; N, 9.92. Found: C, 63.55, H 3.59; N, 9.71.

후처리

  1. filtrationThe mixture was filtered
  2. washthe solid washed with ethanol
  3. dissolutionThe solid was dissolved with ethyl acetate
  4. washwashed with water
  5. dry with materialdried over sodium sulfate
  6. concentrationconcentrated

출처 및 근거

ORD 기록
ord-7b51c3400761410e99d3cccc7aceea58
출처 데이터셋
uspto-grants-1997_04
특허 번호
US05624937

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