Cesium carbonate → HCID 57426193, 화합물

HRID 551027노트

반응식

HRID 551027 반응식
C(=O)([O-])[O-].[Cs+].[Cs+].[N+:7]([C:10]1[C:18]2[NH:17][C:16](=[O:19])[NH:15][C:14]=2[CH:13]=[CH:12][CH:11]=1)([O-:9])=[O:8].Br[CH2:21][C:22]([O:24][C:25]([CH3:28])([CH3:27])[CH3:26])=[O:23]>>[N+:7]([C:10]1[C:18]2[NH:17][C:16](=[O:19])[N:15]([CH2:21][C:22]([O:24][C:25]([CH3:28])([CH3:27])[CH3:26])=[O:23])[C:14]=2[CH:13]=[CH:12][CH:11]=1)([O-:9])=[O:8]

참가 물질

4

반응물 3

HCID 10796Cesium carbonateHCID 79177tert-Butyl bromoacetateHCID 41498284-Nitro-1H-benzo[d]imidazol-2(3H)-one2회

생성물 1

HCID 57426193HCID 57426193, 화합물

실험 절차

Cesium carbonate (1.75 g, 5.4 mmol) was added to a solution of 4-nitro-1,3-dihydro-2H-benzimidazol-2-one (800 mg, 4.5 mmol, described in Intermediate 26) and tert-butyl bromoacetate (0.791 mL, 5.4 mmol) in DM (15 mL). After 18 h, the reaction was quenched with H2O (100 mL) and the solid precipitate was collected by filtration. The crude product was purified by silica gel chromatography, eluting with CH2Cl2:MeOH—95:5, to give the title compound. MS: m/z=294 (M+1).

후처리

  1. customthe reaction was quenched with H2O (100 mL)
  2. filtrationthe solid precipitate was collected by filtration
  3. customThe crude product was purified by silica gel chromatography
  4. washeluting with CH2Cl2

출처 및 근거

ORD 기록
ord-a0c1a45ebade4fae81459ac08093e97d
출처 데이터셋
uspto-grants-2011_05
특허 번호
US07947677B2

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