Urea → 4,6-dichloro-1,3-dihydro-2H-Imidazo[4,5-c]pyridin-2-one
반응식
[Cl:1][C:2]1[C:7]([NH2:8])=[C:6]([NH2:9])[CH:5]=[C:4]([Cl:10])[N:3]=1.N[C:12](N)=[O:13]>O>[Cl:1][C:2]1[C:7]2[NH:8][C:12](=[O:13])[NH:9][C:6]=2[CH:5]=[C:4]([Cl:10])[N:3]=1참가 물질
4
반응 조건
- 온도
- 165 °C
실험 절차
A mixture of 2,6-dichloro-3,4-dihydropyridine-3,4-diamine (500 mg, 2.8 mmol) from Step B and urea (1.0 g, 16.8 mmol) was stirred as a melt at 165° C. for 4 h, then cooled and H2O (100 mL) was added. The aqueous mixture was heated at reflux until all solid dissolved and the solution was allowed to cool and aged for 18 h. The precipitate was isolated by filtration to give the title compound. MS: m/z=205 (M+1).
후처리
- temperaturecooled
- temperatureThe aqueous mixture was heated
- temperatureat reflux until all solid
- dissolutiondissolved
- temperatureto cool
- waitaged for 18 h
- customThe precipitate was isolated by filtration
출처 및 근거
- ORD 기록
- ord-ca2ec2b7a1a24ec797526d19ed8d5f68
- 출처 데이터셋
- uspto-grants-2011_05
- 특허 번호
- US07947677B2
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