Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-(Trifluoromethyl)phenol → 2-(3-Thienylmethyloxy)-6-(meta-trifluoromethylphenoxy)pyridine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-(Trifluoromethyl)phenol | HCID 7376 | — |
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | 2-Chloro-6-(3-thienylmethyloxy)pyridine | HCID 19957413 | — |
| 촉매 | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 2-(3-Thienylmethyloxy)-6-(meta-trifluoromethylphenoxy)pyridine | HCID 19957405 | — |
반응 단계
To a solution containing meta-trifluoromethylphenol (3.62 g, 0.0045×5.0 mol), sodium hydride (0.89 g, (Ca.60% in mineral oil), 0.0045×5.0 mol) and CuI (0.42 g, 0.0045×0.5 mol) in dimethylformamide, 2-chloro-6-(3-thienylmethyloxy)pyridine (1.0 g, 0.0045 mol) was added and the resultant solution was refluxed for about 3 hours.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05624942 |
| 출처 데이터셋 | uspto-grants-1997_04 |
| ORD ID | ord-6b619584c6cc4a48a4c6205325942da5 |
| 출처 메모 | uspto-grants-1997_04 |