Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → HCID 67048682, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | 2-Chloro-p-toluidine | HCID 12007 | — |
| 반응물 | 4-Chlorobutane-1-sulphonyl chloride | HCID 74212 | — |
| 용매 | Pyridine | HCID 1049 | — |
| 생성물 | HCID 67048682 | HCID 67048682 | — |
반응 단계
1.30 ml (10.7 mmol) 2-chloro-4-methyl-aniline are placed in 30 ml of pyridine, combined with 2.67 g (10.5 mmol) 75% m 4-chlorobutyl-sulphonic acid chloride and stirred for 16 hours at ambient temperature. The reaction mixture is poured into water and extracted with ethyl acetate. The combined organic phases are washed with 6-molar hydrochloric acid, dried over sodium sulphate and evaporated down i. vac. The residue is purified by chromatography on silica gel (eluting gradient: petroleum ether/ethyl acetate=9:1→7:3).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07947700B2 |
| 출처 데이터셋 | uspto-grants-2011_05 |
| ORD ID | ord-4d703f5426c44af6b1c1cde516e6e502 |
| 출처 메모 | uspto-grants-2011_05 |