Water → 3-Chloro-4-(1,1-dioxo-[1,2]thiazinan-2-yl)-toluene

HRID 551222

반응식

HRID 551222 반응식
[Cl:1][C:2]1[CH:16]=[C:15]([CH3:17])[CH:14]=[CH:13][C:3]=1[NH:4][S:5]([CH2:8][CH2:9][CH2:10][CH2:11]Cl)(=[O:7])=[O:6].[K].CC(C)([O-])C.O>CN(C=O)C>[Cl:1][C:2]1[CH:16]=[C:15]([CH3:17])[CH:14]=[CH:13][C:3]=1[N:4]1[CH2:11][CH2:10][CH2:9][CH2:8][S:5]1(=[O:7])=[O:6]

참가 물질

5

반응물 3

HCID 962WaterHCID 50987170Potassium tertbutoxideHCID 670486822-chloro-N-(4-chlorobutyl-sulphonyl)-4-methyl-aniline

생성물 1

HCID 667317213-Chloro-4-(1,1-dioxo-[1,2]thiazinan-2-yl)-toluene

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

1.27 g (4.29 mmol) 2-chloro-N-(4-chlorobutyl-sulphonyl)-4-methyl-aniline are stirred together with 722 mg (6.43 mmol) potassium-tert.-butoxide in 50 ml DMF for 16 hours at 60° C. Then the reaction mixture is poured into water and extracted with ethyl acetate. The combined organic phases are dried over sodium sulphate and evaporated down i. vac. The residue is purified by chromatography on silica gel (eluant: petroleum ether/ethyl acetate=3:2).

후처리

  1. extractionextracted with ethyl acetate
  2. dry with materialThe combined organic phases are dried over sodium sulphate
  3. customevaporated down i
  4. customThe residue is purified by chromatography on silica gel (eluant: petroleum ether/ethyl acetate=3:2)

출처 및 근거

ORD 기록
ord-b68109bcc540492b88f56ca57a1e6150
출처 데이터셋
uspto-grants-2011_05
특허 번호
US07947700B2

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