Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 2-Chloro-4-cyano-6-(3-thienylmethyloxy)pyridine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | Thiophene-3-methanol | HCID 123570 | — |
| 반응물 | 2,6-Dichloroisonicotinonitrile | HCID 735906 | — |
| 용매 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 생성물 | 2-Chloro-4-cyano-6-(3-thienylmethyloxy)pyridine | HCID 19957389 | — |
반응 단계
Sodium hydride (0.24 g (ca.60% in mineral oil), 0.006×1.0 mol) was suspended in 20 ml of N-methyl-2-pyrrolidinone, and 3-thiophenemethanol (0.69 g, 0.006×1.0 mol) was added thereto and the resultant solution was stirred for about 30 minutes at room temperature. The resultant mixture was cooled to 4° C. with iced water, then 4-cyano-2,6-dichloropyridine (1.04 g, 0.006 mol) was added thereto and stirred for about 1.5 hour while cooling with iced water.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05624942 |
| 출처 데이터셋 | uspto-grants-1997_04 |
| ORD ID | ord-eece5abd52194311a31191def6bbd1aa |
| 출처 메모 | uspto-grants-1997_04 |