Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium hydride → 2-Chloro-6-(3-thienylmethyloxy)-4-trifluoromethylpyridine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | Thiophene-3-methanol | HCID 123570 | — |
| 반응물 | 2,6-Dichloro-4-(trifluoromethyl)pyridine | HCID 520968 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 2-Chloro-6-(3-thienylmethyloxy)-4-trifluoromethylpyridine | HCID 19957414 | — |
반응 단계
To a mixture prepared by adding to 3-thiophenemethanol (1.27 g, 0.0093×1.2 mol) successively tetrahydrofuran and sodium hydride (0.39 g, (ca.60% in mineral oil), 0.0093×1.05 mol), 2,6-dichloro-4-trifluoromethylpyridine (2.0 g, 0.0093 mol) was added, and the resultant solution was refluxed for about 1 hour.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05624942 |
| 출처 데이터셋 | uspto-grants-1997_04 |
| ORD ID | ord-6dc248110a614616b79bd00cf79a9a93 |
| 출처 메모 | uspto-grants-1997_04 |