1-(3-chloro-4-methylphenyl)ethanone → HCID 86631563, 화합물

HRID 551329노트

반응식

HRID 551329 반응식
[Br:1][C:2]1[CH:3]=[C:4]([C:10](=[O:15])[C:11]([F:14])([F:13])[F:12])[CH:5]=[C:6]([Br:9])[C:7]=1[F:8].[Cl:16][C:17]1[CH:18]=[C:19]([C:24](=[O:26])[CH3:25])[CH:20]=[CH:21][C:22]=1[CH3:23]>C(OCC)(=O)C>[Cl:16][C:17]1[CH:18]=[C:19]([C:24](=[O:26])[CH2:25][C:10]([C:4]2[CH:3]=[C:2]([Br:1])[C:7]([F:8])=[C:6]([Br:9])[CH:5]=2)([OH:15])[C:11]([F:14])([F:12])[F:13])[CH:20]=[CH:21][C:22]=1[CH3:23]

참가 물질

4

반응물 2

HCID 3429151-(3-chloro-4-methylphenyl)ethanoneHCID 86631564HCID 86631564, 화합물

생성물 1

HCID 86631563HCID 86631563, 화합물수율 95.4%

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

반응 조건

온도
50 °C

실험 절차

To a stirred solution of 1-(3,5-dibromo-4-fluorophenyl)-2,2,2-trifluoroethanone (0.99 g) and 1-(3-chloro-4-methylphenyl)ethanone (0.48 g) in ethyl acetate (3 mL) was added dithylamine (0.062 g). The mixture was stirred at 50° C. for 2 hours. The reaction mixture was then concentrated under reduced pressure and the crude product was purified by liquid chromatography (medium pressure collection apparatus: Purif-α2 manufactured by Moritex Corporation) eluted with ethyl acetate-hexane (1:10) to afford the title compound as a pale yellow oil (1.40 g).

후처리

  1. concentrationThe reaction mixture was then concentrated under reduced pressure
  2. customthe crude product was purified by liquid chromatography (medium pressure collection apparatus: Purif-α2 manufactured by Moritex Corporation)
  3. washeluted with ethyl acetate-hexane (1:10)

출처 및 근거

ORD 기록
ord-7a2c1f301ea0451eb9cc9cbec4814542
출처 데이터셋
uspto-grants-2011_05
특허 번호
US07947715B2

반응 노트

불러오는 중…