Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium hydride → 2-Chloro-4-methylamino-6-(3-thienylmethyloxy)pyridine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | Thiophene-3-methanol | HCID 123570 | — |
| 반응물 | 2,6-Dichloro-N-methylpyridin-4-amine | HCID 19957394 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 2-Chloro-4-methylamino-6-(3-thienylmethyloxy)pyridine | HCID 19957411 | — |
반응 단계
To a solution of 3-thiophenemethanol (1.42 g, 0.0113×1.1 mol) in 20 ml of dry tetrahydrofuran, sodium hydride (1.35 g (ca.60% in mineral oil), 0.0113×3.0 mol) was added. After the bubbling ceased, a solution of 2,6-dichloro-4-methylaminopyridine (2.0 g, 0.0113 mol) in 30 ml of dry tetrahydrofuran was added dropwise at room temperature.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05624942 |
| 출처 데이터셋 | uspto-grants-1997_04 |
| ORD ID | ord-ed7deb2ac47349c198c996cbb3ace623 |
| 출처 메모 | uspto-grants-1997_04 |