Ethylamine → 3-(Ethylamino)-1,1,1-trifluoro-2-{[(1-phenyl-1H-indazol-4-yl)amino]methyl}-2-propanol

HRID 551428노트

반응식

HRID 551428 반응식
[C:1]1([N:7]2[C:15]3[CH:14]=[CH:13][CH:12]=[C:11]([NH:16][CH2:17][C:18]4([C:21]([F:24])([F:23])[F:22])[CH2:20][O:19]4)[C:10]=3[CH:9]=[N:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:25]([NH2:27])[CH3:26]>O1CCCC1>[CH2:25]([NH:27][CH2:20][C:18]([CH2:17][NH:16][C:11]1[CH:12]=[CH:13][CH:14]=[C:15]2[C:10]=1[CH:9]=[N:8][N:7]2[C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1)([OH:19])[C:21]([F:24])([F:23])[F:22])[CH3:26]

참가 물질

4

반응물 2

HCID 6341EthylamineHCID 249380531-Phenyl-N-{[2-(trifluoromethyl)-2-oxiranyl]methyl}-1H-indazol-4-amine

생성물 1

HCID 593241573-(Ethylamino)-1,1,1-trifluoro-2-{[(1-phenyl-1H-indazol-4-yl)amino]methyl}-2-propanol

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of 1-phenyl-N-{[2-(trifluoromethyl)-2-oxiranyl]methyl}-1H-indazol-4-amine (1.235 g, 3.7 mmol) in anhydrous tetrahydrofuran (5 ml) was added ethylamine (2M in tetrahydrofuran) (10 ml, 20 mmol). The reaction was stirred at room temperature for approximately 72 hours and then evaporated in vacuo to give the title compound.

후처리

  1. customevaporated in vacuo

출처 및 근거

ORD 기록
ord-0b4b2774ad004c15abf2e7cbc7523362
출처 데이터셋
uspto-grants-2011_05
특허 번호
US07947727B2

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